Yamada Satoru, Ano Natsuko, Toda Kyoko, Kitaoka Akira, Shiono Kaoru, Inoue Gaku, Atsuda Koichiro, Irie Junichiro
Department of Internal Medicine, Kitasato Institute Hospital, Tokyo, Japan.
Hypertens Res. 2008 Apr;31(4):601-6. doi: 10.1291/hypres.31.601.
To examine the effects of telmisartan on peroxisome proliferator-activated receptor gamma activation, we compared the effects of telmisartan with those of candesartan on adipocytokines and glucose and lipid metabolism in vivo and in vitro. In vivo, 56 patients with both type 2 diabetes and hypertension were enrolled and randomized to receive either telmisartan (40 mg) or candesartan (8 mg) for 3 months. Serum adiponectin, HbA1c levels, lipid profiles and blood pressure were recorded at the beginning and 3 months later. In vitro, differentiated 3T3-L1 adipocytes were treated with telmisartan, candesartan, pioglitazone or vehicle for 24 h, and then adiponectin mRNA and protein levels were measured. The results showed that most of the metabolic parameters, including the lipid profiles, did not change significantly during the study in either group. However, the changes in serum adiponectin and plasma glucose over 3 months were significantly greater in the telmisartan group than in the candesartan group. In vitro, although the protein level of adiponectin was not significantly elevated, the mRNA expression of adiponectin was elevated 1.5-fold by telmisartan in 3T3-L1 adipocytes. Our findings suggest that telmisartan may have beneficial effects in type 2 diabetes beyond its antihypertensive effect.
为研究替米沙坦对过氧化物酶体增殖物激活受体γ激活的影响，我们在体内和体外比较了替米沙坦与坎地沙坦对脂肪细胞因子以及葡萄糖和脂质代谢的影响。在体内，招募了56例2型糖尿病合并高血压患者，并将其随机分为两组，分别接受替米沙坦（40 mg）或坎地沙坦（8 mg）治疗3个月。在研究开始时及3个月后记录血清脂联素、糖化血红蛋白水平、血脂谱和血压。在体外，将分化的3T3-L1脂肪细胞用替米沙坦、坎地沙坦、吡格列酮或赋形剂处理24小时，然后测量脂联素mRNA和蛋白水平。结果显示，在研究期间，两组的大多数代谢参数，包括血脂谱，均无显著变化。然而，替米沙坦组血清脂联素和血浆葡萄糖在3个月内的变化显著大于坎地沙坦组。在体外，虽然脂联素的蛋白水平没有显著升高，但替米沙坦使3T3-L1脂肪细胞中脂联素的mRNA表达升高了1.5倍。我们的研究结果表明，替米沙坦在2型糖尿病中可能除了具有降压作用外，还具有有益作用。
