Ebina Kosuke, Fukuhara Atsunori, Ando Wataru, Hirao Makoto, Koga Tadashi, Oshima Kazuya, Matsuda Morihiro, Maeda Kazuhisa, Nakamura Tadashi, Ochi Takahiro, Shimomura Iichiro, Yoshikawa Hideki, Hashimoto Jun
Department of Orthopaedics, Graduate School of Medicine, Osaka University, 2-2 Yamadaoka, Suita, Osaka 565-0871, Japan.
Clin Rheumatol. 2009 Apr;28(4):445-51. doi: 10.1007/s10067-008-1074-y. Epub 2008 Dec 16.
Adiponectin is a hormone released by adipose tissue with antidiabetic, antiatherogenic, and anti-inflammatory properties. The present observational study focused on the relation between serum adiponectin level and the disease severity of established rheumatoid arthritis (RA). Ninety patients with more than 5-year diagnosis of RA and 42 age- and BMI-matched control were enrolled. The severity of RA was evaluated according to the number of destructed joints of overall 68 joints on plain radiographs (37 patients had mild RA and 53 had severe RA). Serum adiponectin level was significantly higher in the severe RA group (17.7+/-6.7 microg/ml) than in the control (9.1+/-3.8 microg/ml) and mild RA groups (13.9+/-6.5 microg/ml) (control vs. mild RA group, P<0.001; mild RA vs. severe RA group, P<0.01). These results suggest that increased number of joint destruction is associated with hyperadiponectinemia in established RA patients.
脂联素是一种由脂肪组织释放的激素，具有抗糖尿病、抗动脉粥样硬化和抗炎特性。本观察性研究聚焦于血清脂联素水平与已确诊类风湿关节炎（RA）疾病严重程度之间的关系。纳入了90例诊断为RA超过5年的患者以及42例年龄和体重指数相匹配的对照。根据X线平片上68个关节中破坏关节的数量评估RA的严重程度（37例患者为轻度RA，53例为重度RA）。重度RA组的血清脂联素水平（17.7±6.7微克/毫升）显著高于对照组（9.1±3.8微克/毫升）和轻度RA组（13.9±6.5微克/毫升）（对照组与轻度RA组比较，P<0.001；轻度RA组与重度RA组比较，P<0.01）。这些结果表明，在已确诊的RA患者中，关节破坏数量增加与高脂联素血症相关。
