Nomura Hisanaga, Kawakami Hideyasu, Nagai Shigeru, Shinohara Takao, Imoto Shigeru, Isaka Hirotsugu
Dept. of Pharmacy, Kyorin University Hospital.
Gan To Kagaku Ryoho. 2008 Jun;35(6):941-6.
It is largely believed that nausea/vomiting during cancer chemotherapy is caused by both the medical and personal factors of the patient. This study was aimed at examining whether the monitoring of risk factors prior to the therapy would help predict nausea/vomiting.
In the fifteen months between April 2006 and June 2007, breast cancer patients, receiving FEC and AC chemotherapy at the Outpatient Chemotherapy Room, were interviewed. Before they received their first treatment, each patient was asked to reply as to five risk factors: age, history of motion sickness, habitual drinking, history of morning sickness, and anxiety. Three weeks later, when they came back for their second treatment, CTCAE was conducted to assess their symptoms of nausea and vomiting. Fisher's exact probability test was used for the statistical analysis.
49 patients were studied. The relative risk ratios of vomiting were as follows: Age 1.57; motion sickness 2.15; habitual drinking 0.97; morning sickness 1.54; and anxiety 3.15. Only anxiety showed a significant difference(p=0.019). The associated risk ratios of nausea were: age 2.00; motion sickness 1.57; habitual drinking 1.04; morning sickness 1.37; and high levels of anxiety 2.28. Only anxiety showed a significant difference(p=0.018). The number of risk factors did not show a significant difference.
The study shows that anxiety may be one of the risk factors that would cause severe nausea or vomiting during cancer chemotherapy.
人们普遍认为，癌症化疗期间的恶心/呕吐是由患者的医学因素和个人因素共同引起的。本研究旨在探讨在治疗前对危险因素进行监测是否有助于预测恶心/呕吐。
在2006年4月至2007年6月的15个月间，对在门诊化疗室接受FEC和AC化疗的乳腺癌患者进行了访谈。在他们接受首次治疗前，每位患者被要求回答五个危险因素：年龄、晕动病史、习惯性饮酒、晨吐史和焦虑情况。三周后，当他们回来接受第二次治疗时，采用癌症治疗不良反应通用术语标准（CTCAE）来评估他们的恶心和呕吐症状。采用Fisher精确概率检验进行统计分析。
共研究了49例患者。呕吐的相对风险比分别如下：年龄1.57；晕动病2.15；习惯性饮酒0.97；晨吐1.54；焦虑3.15。只有焦虑显示出显著差异（p=0.019）。恶心的相关风险比分别为：年龄2.00；晕动病1.57；习惯性饮酒1.04；晨吐1.37；高度焦虑2.28。只有焦虑显示出显著差异（p=0.018）。危险因素的数量未显示出显著差异。
该研究表明，焦虑可能是导致癌症化疗期间严重恶心或呕吐的危险因素之一。
