Takayama Tetsuji, Okamura Seisuke, Okahisa Toshiya, Kaji Masako, Takeuchi Hisashi, Kimura Tetsuo
Dept. of Gastroenterology and Oncology, Institutes of Health Biosciences, University of Tokushima Graduate School, Tokushima, Japan.
Gan To Kagaku Ryoho. 2008 Jul;35(7):1067-71.
Cancer chemoprevention is the use of agents to inhibit, delay or reverse carcinogenesis, and was proposed in the United States in view of the cost-benefits. Since recent progress in molecular biology revealed several signal transduction routes in carcinogenesis, the search for mechanism-based chemopreventive agents is under way. Many chemopreventive clinical trials for various cancers including colorectal cancer, prostate cancer and breast cancer, have been performed. Chemoprevention to eradicate viruses or bacteria such as hepatitis viruses or Helicobacter pylori is also important in order to prevent development of cancer.
癌症化学预防是指使用药物抑制、延缓或逆转癌症发生，鉴于其成本效益，这一概念由美国提出。由于分子生物学的最新进展揭示了癌症发生过程中的几种信号转导途径，基于机制的化学预防药物的研究正在进行中。针对包括结直肠癌、前列腺癌和乳腺癌在内的各种癌症，已经开展了许多化学预防临床试验。为预防癌症发展，根除病毒或细菌（如肝炎病毒或幽门螺杆菌）的化学预防也很重要。
