Condon C D, Weinberger N M
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Behav Neurosci. 1991 Jun;105(3):416-30. doi: 10.1037//0735-7044.105.3.416.
Associative learning produces conditioned stimulus (CS)-specific plasticity of frequency receptive fields (RFs) in the auditory cortex; responses to the CS frequency are increased, whereas responses to other frequencies are decreased. This study determined the effects of habituation on the RF of neurons in the auditory cortex of the guinea pig (Cavia porcellus). One frequency was presented repeatedly (REP) followed by redetermination of the RF. After REP, 26/36 (72%) RFs exhibited a substantial reduction (70-75%) of response to the repeated frequency, and this was highly specific (bandwidth less than 0.125 octave). This RF plasticity involves an initial decrease in response during REP but does not require attenuated responses at the end of REP. Incubation (i.e., development over time after cessation of REP) and long-term frequency-specific effects are evident. Thus, habituation induces a specific change in the processing of frequency information rather than a general reduction in responsivity.
联合学习在听觉皮层中产生条件刺激（CS）特异性的频率感受野（RF）可塑性；对CS频率的反应增强，而对其他频率的反应减弱。本研究确定了习惯化对豚鼠（Cavia porcellus）听觉皮层神经元RF的影响。重复呈现一个频率（REP），随后重新测定RF。REP后，26/36（72%）的RF对重复频率的反应大幅降低（70 - 75%），且具有高度特异性（带宽小于0.125倍频程）。这种RF可塑性涉及REP期间反应的初始降低，但在REP结束时不需要反应减弱。潜伏期（即REP停止后的随时间发展）和长期频率特异性效应是明显的。因此，习惯化诱导频率信息处理的特异性变化，而非反应性的普遍降低。
