Bakin J S, Lepan B, Weinberger N M
Center for the Neurobiology of Learning and Memory, University of California, Irvine 92717.
Brain Res. 1992 Apr 17;577(2):226-35. doi: 10.1016/0006-8993(92)90278-h.
Sensitization training with an auditory stimulus produces a general increase in response magnitude across the entire receptive field (RF) of neurons in the primary auditory cortex of the guinea pig (Bakin, J.S. and Weinberger, N.M., Brain Res., 536 (1990) 271-286). To determine if this effect reflects an auditory system-specific process or is caused by a process independent of the training stimulus modality, RFs in primary auditory cortex were characterized before and immediately after adult guinea pigs were given sensitization training with either an auditory or a visual training stimulus. General increases in auditory response magnitude across the RF were observed in 7 out of 7 auditory sensitization cases and 4 out of 5 visual sensitization cases. There were no statistical differences between the effects of auditory and visual sensitization training. These findings indicate that the general increases observed following sensitization training are the result of processes independent of CS modality, in contrast to the highly specific RF modifications that are caused by classical conditioning. The findings suggest that the 2 forms of RF plasticity, CS-specific re-tuning due to associative conditioning and polymodal general increases in gain due to non-associative sensitization, may reflect neural mechanisms involved in selective attention and vigilance, respectively.
用听觉刺激进行的敏化训练会使豚鼠初级听觉皮层中神经元的整个感受野（RF）的反应幅度普遍增加（巴金，J.S.和温伯格，N.M.，《大脑研究》，536（1990）271 - 286）。为了确定这种效应是反映了特定于听觉系统的过程，还是由独立于训练刺激模式的过程引起的，在成年豚鼠接受听觉或视觉训练刺激的敏化训练之前和之后立即对初级听觉皮层中的感受野进行了表征。在7例听觉敏化案例中的7例以及5例视觉敏化案例中的4例中，观察到整个感受野的听觉反应幅度普遍增加。听觉和视觉敏化训练的效果之间没有统计学差异。这些发现表明，与经典条件作用引起的高度特异性感受野改变相反，敏化训练后观察到的普遍增加是独立于条件刺激模式的过程的结果。这些发现表明，两种形式的感受野可塑性，即由于联合条件作用导致的条件刺激特异性重新调整，以及由于非联合敏化导致的多模式增益普遍增加，可能分别反映了参与选择性注意和警觉的神经机制。
