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南亚的狂犬病:流行病学调查与临床视角

Rabies in South Asia: epidemiological investigations and clinical perspective.

作者信息

Singh C K, Sandhu B S

机构信息

Department of Veterinary Pathology, College of Veterinary Science, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab, India.

出版信息

Dev Biol (Basel). 2008;131:133-6.

PMID:18634472
Abstract

A five year study (1995-1999) was conducted in Northern India to investigate epidemiological aspects of rabies in domestic animals. For this purpose, brain tissue samples were collected from rabies suspect animals including 231 dogs, 79 buffaloes, 46 cattle and 28 wild species. Out of the 384 rabies suspected cases, 56% were positive for rabies by fluorescent antibody test (FAT), the mouse inoculation test (MIT) and histopathological techniques. Variations in clinical signs of rabies were recorded for individual animals with significant differences observed between dogs and bovines with respect to hypersalivation, paralysis, recognition of owners and aggression. Likewise, differences in the clinical course of disease between cows and buffaloes regarding hypersalivation and micturition were observed. Rabies incidence was highest among adult male dogs and indicated a seasonal pattern with more rabies cases during certain months of the year (January to April, and August to November). Its impact on cow/buffalo rabies is discussed. Accumulated history records revealed that 78% of owned rabid dogs were not prophylactically vaccinated against rabies.

摘要

在印度北部开展了一项为期五年(1995 - 1999年)的研究,以调查家畜狂犬病的流行病学情况。为此,从疑似患有狂犬病的动物身上采集了脑组织样本,这些动物包括231只狗、79头水牛、46头牛和28种野生动物。在384例疑似狂犬病病例中,通过荧光抗体试验(FAT)、小鼠接种试验(MIT)和组织病理学技术检测,56%的病例狂犬病呈阳性。记录了每只动物狂犬病临床症状的差异,观察到狗和牛在流涎过多、瘫痪、认出主人和攻击性方面存在显著差异。同样,观察到奶牛和水牛在流涎过多和排尿方面疾病临床过程的差异。成年雄性狗的狂犬病发病率最高,且呈现出季节性模式,一年中的某些月份(1月至4月以及8月至11月)狂犬病病例较多。文中讨论了其对奶牛/水牛狂犬病的影响。累积的历史记录显示,78%的家养狂犬病狗未接受过狂犬病预防性疫苗接种。

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