Haber Michael, Murai Keith K
Centre for Research in Neuroscience, The Research Institute of the McGill University Health Centre, Montreal General Hospital, Canada.
Neuron Glia Biol. 2006 Feb;2(1):59-66. doi: 10.1017/S1740925X06000032.
Neuron-glial interactions in the nervous system are of fundamental importance to many processes including neural migration,axon guidance, myelination and synaptic transmission. At synapses in the CNS, the physiological and structural relationship between neurons and astrocytes is particularly complex. The juxtaposition of astrocytic membranes with presynaptic and postsynaptic elements is important for regulating synaptic transmission and plasticity. Recent investigations demonstrate that the morphology of both neuronal and glial components show rapid, continuous structural remodeling in the hippocampus.These physical modifications are likely to have a significant functional impact upon neurotransmission and indicate that there modeling of astrocytic morphology might be crucial for the dynamic regulation of the synapse and its microenvironment. In this review, we focus on the structural complexities of astrocyte-synapse interactions in the hippocampus and their implications for understanding synaptic physiology, behavior and disease.
神经系统中的神经元-胶质细胞相互作用对于包括神经迁移、轴突导向、髓鞘形成和突触传递在内的许多过程至关重要。在中枢神经系统的突触处，神经元与星形胶质细胞之间的生理和结构关系尤为复杂。星形胶质细胞膜与突触前和突触后元件的并列对于调节突触传递和可塑性很重要。最近的研究表明，海马体中神经元和胶质细胞成分的形态都显示出快速、持续的结构重塑。这些物理改变可能对神经传递产生重大功能影响，并表明星形胶质细胞形态的重塑可能对突触及其微环境的动态调节至关重要。在这篇综述中，我们重点关注海马体中星形胶质细胞-突触相互作用的结构复杂性及其对理解突触生理学、行为和疾病的意义。
