Rosendahl Mikkel, Andersen Claus Yding, Ernst Erik, Westergaard Lars G, Rasmussen Per Emil, Loft Anne, Andersen Anders Nyboe
Laboratory of Reproductive Biology, Copenhagen University Hospital, Rigshospitalet, Denmark.
Hum Reprod. 2008 Nov;23(11):2475-83. doi: 10.1093/humrep/den248. Epub 2008 Jul 17.
Ovarian function was studied in Danish patients who had ovarian tissue cryopreserved, and the patients' experiences with the procedure were investigated.
There were 92 women who had an entire ovary removed for cryopreservation 18-75 months earlier. Reasons included: breast cancer (n = 31; 34%), Hodgkin's lymphoma (n = 23; 25%), bone marrow transplantation (BMT) (n = 19; 21%) and others (n = 19; 21%). Patients completed a questionnaire, and transvaginal ultrasonic antral follicle count and serum analysis for follicle stimulating hormone (FSH) and anti-Müllerian hormone (AMH) were performed in 73 women.
In total, 11% of the BMT patients had normal ovarian function. Hodgkin's patients who only received ABVD (doxorubicin, bleomycin, vinblastine and dacarbazine) (n = 12) and 60% of the breast cancer patients showed little evidence of ovarian damage. Regular menstruation was shown to be a good indicator of ovarian function. The cryopreservation procedure rarely complicated cancer treatment (5%) and 84% felt comforted because they had potentially secured their fertility.
Cryopreservation of ovarian tissue should be considered in young female patients with Hodgkin's lymphoma receiving more aggressive treatment than ABVD and in patients scheduled for BMT. The recommendation for breast cancer patient should be individualized. The cryopreservation process did not delay cancer treatment.
对丹麦接受卵巢组织冷冻保存的患者的卵巢功能进行了研究，并调查了患者对该手术的体验。
92名女性在18至75个月前切除了整个卵巢用于冷冻保存。原因包括：乳腺癌（n = 31；34%）、霍奇金淋巴瘤（n = 23；25%）、骨髓移植（BMT）（n = 19；21%）以及其他（n = 19；21%）。患者完成了一份问卷，并对73名女性进行了经阴道超声窦卵泡计数以及卵泡刺激素（FSH）和抗苗勒管激素（AMH）的血清分析。
总体而言，11%的骨髓移植患者卵巢功能正常。仅接受ABVD（多柔比星、博来霉素、长春花碱和达卡巴嗪）方案的霍奇金病患者（n = 12）以及60%的乳腺癌患者几乎没有卵巢损伤的迹象。规律月经被证明是卵巢功能的良好指标。冷冻保存手术很少使癌症治疗复杂化（5%），并且84%的患者因潜在地保障了生育能力而感到安心。
对于接受比ABVD方案更积极治疗的年轻霍奇金淋巴瘤女性患者以及计划进行骨髓移植的患者，应考虑卵巢组织冷冻保存。对于乳腺癌患者的建议应个体化。冷冻保存过程并未延误癌症治疗。
