MacKnight Brenda, Martinez Elizabeth A, Simon Brett A
Department of Anesthesiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21287-8711, USA.
Semin Cardiothorac Vasc Anesth. 2008 Jun;12(2):91-6. doi: 10.1177/1089253208319872.
Advances in the treatment of patients with chronic pulmonary hypertension have greatly improved their functional status and longevity, and increasing numbers of these complex patients are presenting for elective noncardiac surgery. In this communication we will briefly review the classification and pathophysiology of pulmonary hypertension, summarize outpatient pharmacotherapy approaches, and discuss the perioperative preparation and management of these complex patients. With an understanding of the underlying pathophysiology of the disease and pharmacology of these new therapies, combined with careful perioperative planning and care, these patients can safely undergo elective surgical procedures.
慢性肺动脉高压患者治疗方面的进展极大地改善了他们的功能状态和寿命,并且越来越多这类病情复杂的患者前来接受择期非心脏手术。在本交流中,我们将简要回顾肺动脉高压的分类和病理生理学,总结门诊药物治疗方法,并讨论这些病情复杂患者的围手术期准备和管理。了解该疾病的潜在病理生理学以及这些新疗法的药理学,再结合精心的围手术期规划和护理,这些患者能够安全地接受择期手术。