Harrington Eoghan D, Bork Peer
Structural and Computational Biology Unit, European Molecular Biology Laboratory, Meyerhofstrasse 1, 69117 Heidelberg, Germany.
Bioinformatics. 2008 Sep 1;24(17):1959-60. doi: 10.1093/bioinformatics/btn361. Epub 2008 Jul 17.
Sircah is a flexible tool for the detection, analysis and visualization of alternative transcripts. It takes as input gene models or spliced alignments and creates a database of alternative transcription events: alternative transcription initiation and polyadenylation, alternative 3' and 5' splice-site usage, skipped exons and retained introns. The results can be visualized in a variety of ways, allowing the creation of publication quality images.
The Sircah is available for download under a creative commons license along with additional documentation and a tutorial from http://www.bork.embl.de/Sircah.
Sircah是一种用于检测、分析和可视化可变转录本的灵活工具。它以基因模型或剪接比对作为输入,并创建一个可变转录事件数据库:可变转录起始和聚腺苷酸化、可变3'和5'剪接位点使用、外显子跳跃和内含子保留。结果可以通过多种方式进行可视化,从而创建具有发表质量的图像。
Sircah可根据知识共享许可协议进行下载,同时还可从http://www.bork.embl.de/Sircah获取其他文档和教程。