Engels Reinhard, Yu Tamara, Burge Chris, Mesirov Jill P, DeCaprio David, Galagan James E
The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, MA 02142, USA.
Bioinformatics. 2006 Jul 15;22(14):1782-3. doi: 10.1093/bioinformatics/btl193. Epub 2006 May 18.
Combo is a comparative genome browser that provides a dynamic view of whole genome alignments along with their associated annotations. Combo provides two different visualization perspectives. The perpendicular (dot plot) view provides a dot plot of genome alignments synchronized with a display of genome annotations along each axis. The parallel view displays two genome annotations horizontally, synchronized through a panel displaying local alignments as trapezoids. Users can zoom to any resolution, from whole chromosomes to individual bases. They can select, highlight and view detailed information from specific alignments and annotations. Combo is an organism agnostic and can import data from a variety of file formats.
Combo is integrated as part of the Argo Genome Browser which also provides single-genome browsing and editing capabilities. Argo is written in Java, runs on multiple platforms and is freely available for download at http://www.broad.mit.edu/annotation/argo/.
Combo是一个比较基因组浏览器，它能动态展示全基因组比对及其相关注释。Combo提供两种不同的可视化视角。垂直（点图）视图提供基因组比对的点图，并在每个轴上同步显示基因组注释。平行视图水平显示两个基因组注释，通过一个将局部比对显示为梯形的面板实现同步。用户可以将分辨率从整条染色体缩放至单个碱基。他们可以从特定比对和注释中选择、突出显示并查看详细信息。Combo与生物种类无关，能从多种文件格式导入数据。
Combo作为Argo基因组浏览器的一部分进行集成，Argo还提供单基因组浏览和编辑功能。Argo用Java编写，可在多个平台运行，可从http://www.broad.mit.edu/annotation/argo/免费下载。
