NeuroBiz Consulting & Communication, Castres, France.
J Psychopharmacol. 2009 Nov;23(8):967-74. doi: 10.1177/0269881108093582. Epub 2008 Jul 17.
Although the selective serotonin reuptake inhibitors (SSRIs), which are now widely used as a first-line treatment for depression and many other psychiatric conditions, are generally well tolerated, they are not devoid of side effects. Most short-term treatment-related side effects of SSRIs are transient and disappear after a few days or weeks. However, following long-term treatment with the SSRIs, some serious adverse events may occur. Some of them can be difficult to recognise because they can resemble residual symptoms of depression. The most serious can be life threatening. They all have a negative influence on the patient's quality of life and are frequently a prime reason for a lack of long-term compliance with the associated increased risk of recurrence of a depressive episode. This article is an overview of the more common adverse events, which are seen with non-acute treatment with the SSRIs.
尽管选择性 5-羟色胺再摄取抑制剂（SSRIs）现在被广泛用作抑郁症和许多其他精神疾病的一线治疗药物，一般来说具有良好的耐受性，但它们并非没有副作用。大多数短期治疗相关的 SSRIs 副作用是短暂的，几天或几周后就会消失。然而，长期使用 SSRIs 后，可能会出现一些严重的不良反应。其中一些可能难以识别，因为它们可能类似于抑郁症的残留症状。最严重的可能会危及生命。它们都会对患者的生活质量产生负面影响，并且经常是导致缺乏长期依从性和增加抑郁发作复发风险的主要原因。本文概述了在非急性使用 SSRIs 治疗时更常见的不良反应。
