Yaacobi Y, Goldberg E P, Habal M B
Biomedical Engineering Center University of Florida-MAE 317, Gainesville 32611.
J Invest Surg. 1991;4(1):31-6. doi: 10.3109/08941939109140759.
Intraabdominal adhesions continue to pose a potentially serious postoperative clinical problem. Reported here is an experiment designed to study any effect that balanced Ringer's lactate (RL) solution may have on intraabdominal adhesion formation. Surgical trauma was induced in mice by controlled gauze abrasion of one side of the abdominal wall; the opposite side was used as a control. RL irrigation was compared with no irrigation. Adhesions were scored on the basis of incidence (%) and severity (on a 0-10 scale). The abraded right peritoneum exhibited 100% adhesions for both the RL group and the nonirrigated group. However, on the side that was not abraded, the nonirrigated group showed only 30% incidence of adhesions and 1.7 +/- 3.3 severity as compared with 100% adhesions and 7.7 +/- 2.2 severity for the RL group. These results suggest the need for further studies to establish the extent to which irrigation with solutions such as Ringer's lactate or saline may enhance formation of postoperative adhesions.
腹腔粘连仍然是一个潜在的严重术后临床问题。本文报道了一项实验，旨在研究平衡乳酸林格氏液（RL）对腹腔粘连形成可能产生的任何影响。通过用纱布控制摩擦小鼠腹壁的一侧来诱导手术创伤；另一侧用作对照。将RL冲洗与不冲洗进行比较。根据粘连发生率（%）和严重程度（0-10分制）对粘连进行评分。RL组和未冲洗组的右侧磨损腹膜均表现出100%的粘连。然而，在未磨损的一侧，未冲洗组的粘连发生率仅为30%，严重程度为1.7±3.3，而RL组的粘连发生率为100%，严重程度为7.7±2.2。这些结果表明，需要进一步研究以确定用乳酸林格氏液或生理盐水等溶液冲洗可能增强术后粘连形成的程度。
