Fibrin sealant in laparoscopic adhesion prevention in the rabbit uterine horn model.

OBJECTIVE

To assess the effects of fibrin sealant on adhesions after laparoscopic surgery.

DESIGN

Standardized surgical trauma was induced in 60 female rabbits. The animals were randomized in three groups for different adhesion prevention treatment.

SETTING

University research laboratory.

INTERVENTIONS

After standardized trauma was induced, group 1 (n = 20) received no treatment, group 2 animals (n = 20) were injected in the abdominal cavity with 60 mL of Ringer's lactate, and human fibrin sealant was applied on the surgical lesions under laparoscopic vision in group 3 (n = 20).

MAIN OUTCOME MEASURES

Five weeks after laparoscopy, a laparotomy was performed, and the adhesions were scored.

RESULTS

Fourteen of 20 rabbits in the control group (70%) presented postoperative adhesions, 11 of 20 (55%) in the Ringer's group, and 5 of 20 (25%) in the fibrin sealant group. High-score adhesions were seen in 15% of cases in control and Ringer's group and in 5% of cases in the fibrin sealant group.

CONCLUSIONS

When used during laparoscopic surgery, fibrin sealant has a preventive effect on de novo postsurgical adhesions. To assess the efficacy in reproductive surgery, a trial on recurrent postsurgical adhesions is required.