De Iaco P, Costa A, Mazzoleni G, Pasquinelli G, Bassein L, Marabini A
S. Orsola Hospital, University of Bologna, Italy.
Fertil Steril. 1994 Aug;62(2):400-4. doi: 10.1016/s0015-0282(16)56897-6.
To assess the effects of fibrin sealant on adhesions after laparoscopic surgery.
Standardized surgical trauma was induced in 60 female rabbits. The animals were randomized in three groups for different adhesion prevention treatment.
University research laboratory.
After standardized trauma was induced, group 1 (n = 20) received no treatment, group 2 animals (n = 20) were injected in the abdominal cavity with 60 mL of Ringer's lactate, and human fibrin sealant was applied on the surgical lesions under laparoscopic vision in group 3 (n = 20).
Five weeks after laparoscopy, a laparotomy was performed, and the adhesions were scored.
Fourteen of 20 rabbits in the control group (70%) presented postoperative adhesions, 11 of 20 (55%) in the Ringer's group, and 5 of 20 (25%) in the fibrin sealant group. High-score adhesions were seen in 15% of cases in control and Ringer's group and in 5% of cases in the fibrin sealant group.
When used during laparoscopic surgery, fibrin sealant has a preventive effect on de novo postsurgical adhesions. To assess the efficacy in reproductive surgery, a trial on recurrent postsurgical adhesions is required.
评估纤维蛋白密封剂对腹腔镜手术后粘连的影响。
对60只雌性兔子造成标准化手术创伤。将动物随机分为三组进行不同的粘连预防治疗。
大学研究实验室。
造成标准化创伤后，第1组（n = 20）不接受治疗，第2组动物（n = 20）腹腔内注射60 mL乳酸林格液，第3组（n = 20）在腹腔镜视野下将人纤维蛋白密封剂应用于手术创口。
腹腔镜检查5周后，进行剖腹手术并对粘连进行评分。
对照组20只兔子中有14只（70%）出现术后粘连，乳酸林格液组20只中有11只（55%），纤维蛋白密封剂组20只中有5只（25%）。对照组和乳酸林格液组15%的病例出现高分粘连，纤维蛋白密封剂组为5%。
在腹腔镜手术中使用时，纤维蛋白密封剂对术后新发粘连有预防作用。为评估其在生殖手术中的疗效，需要进行复发性术后粘连的试验。
