表面铁沉积症：阿尔茨海默病中脑淀粉样血管病的潜在诊断标志物。
Superficial siderosis: a potential diagnostic marker of cerebral amyloid angiopathy in Alzheimer disease.
作者信息
Feldman Howard H, Maia Luis F, Mackenzie Ian R A, Forster Bruce B, Martzke Jeff, Woolfenden Andrew
出版信息
Stroke. 2008 Oct;39(10):2894-7. doi: 10.1161/STROKEAHA.107.510826. Epub 2008 Jul 17.
BACKGROUND AND PURPOSE
Superficial siderosis of the central nervous system results from chronic bleeding in the superficial layers of the cortex and spinal cord. In cerebral amyloid angiopathy (CAA), there is amyloid deposition in meningeal and meningo-cortical arteries and capillaries, predisposing them to rupture. CAA is frequently associated with Alzheimer disease (AD).
METHODS
We report a series of 3 AD patients with MRI evidence of superficial siderosis. Two had neuropathological examination confirming superficial siderosis, AD, and CAA.
CONCLUSIONS
Superficial siderosis should be recognized within the spectrum of AD with CAA and considered as a possible antemortem diagnostic feature.
背景与目的
中枢神经系统表面铁沉积症由皮质和脊髓表层的慢性出血所致。在脑淀粉样血管病（CAA）中，脑膜和脑膜皮质动脉及毛细血管中有淀粉样物质沉积，使其易于破裂。CAA常与阿尔茨海默病（AD）相关。
方法
我们报告了3例有MRI证据显示存在表面铁沉积症的AD患者。其中2例经神经病理学检查证实存在表面铁沉积症、AD和CAA。
结论
在伴有CAA的AD范围内应认识到表面铁沉积症，并将其视为一种可能的生前诊断特征。
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