Wilkinson S, Farrelly S, Low J, Chakraborty A, Williams R, Wilkinson S
Department of Mental Health Sciences, Royal Free and University College Medical School, The Hampstead Campus, London, UK.
Eur J Cancer Care (Engl). 2008 Sep;17(5):492-9. doi: 10.1111/j.1365-2354.2007.00904.x. Epub 2008 Jul 10.
The study aims were to determine the use of complementary therapies (CT) by men with prostate cancer, and to explore factors influencing CT use and attitudes toward CT use. A cross-sectional survey design was used in which a postal questionnaire was mailed to an eligible sample of 405 patients with prostate cancer receiving outpatient treatment in a London teaching hospital. The primary outcomes were the prevalence of CT use and the relationship between CT use and mental health status. Two hundred and ninety-four patients (73%) responded, of whom 25% were using CT. The most frequently used CTs were vitamins, low-fat diets, lycopene and green tea. Multivariate analyses revealed no differences in mental health scores between CT users and non-users. CT users were younger (OR 0.93, 95% CI 0.89-0.97) and were more likely to be receiving conservative management in the form of 'active surveillance' (OR 5.23, 95% CI 1.78-15.41) compared with non-users. Over half of the participants (55%) wanted to learn more about CT. Forty-three per cent of CT users had not informed any doctor about their CT use. Clinicians need to be aware of the prevalence of CT use amongst patients with prostate cancer, considering the potential harm that could be caused by interactions with conventional treatments.
该研究的目的是确定前列腺癌男性患者使用补充疗法（CT）的情况，并探讨影响CT使用的因素以及对CT使用的态度。采用横断面调查设计，向伦敦一家教学医院接受门诊治疗的405名前列腺癌合格患者样本邮寄了一份邮政调查问卷。主要结果是CT使用的患病率以及CT使用与心理健康状况之间的关系。294名患者（73%）做出了回应，其中25%正在使用CT。最常用的CT包括维生素、低脂饮食、番茄红素和绿茶。多变量分析显示，CT使用者和非使用者在心理健康评分上没有差异。与非使用者相比，CT使用者更年轻（比值比[OR]0.93，95%置信区间[CI]0.89 - 0.97），并且更有可能接受“主动监测”形式的保守治疗（OR 5.23，95% CI 1.78 - 15.41）。超过一半的参与者（55%）希望了解更多关于CT的信息。43%的CT使用者未告知任何医生他们使用CT的情况。考虑到与传统治疗相互作用可能造成的潜在危害，临床医生需要了解前列腺癌患者中CT使用的患病率。
