Zhang Ling, Zhou Xiao-Nong
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, MOH, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2008 Feb 28;26(1):58-62.
Pharmacological actions of praziquantel against schistosome adult worms are thought to be directly linked to the disruption of Ca2+ homeostasis. The voltage-gated Ca2+ channel is an important factor in regulating the intracellular Ca2+ level. Studies have revealed that Ca2+ channel subunits may be the target for the action of praziquantel. This review summarizes the progress on the structure and function of the Ca2+ channel of Schistosoma spp and other Platyhelminths as well as the role of Ca2+ channel in action of praziquantel.
吡喹酮对血吸虫成虫的药理作用被认为与破坏钙离子稳态直接相关。电压门控钙离子通道是调节细胞内钙离子水平的一个重要因素。研究表明，钙离子通道亚基可能是吡喹酮作用的靶点。本文综述了血吸虫及其他扁形虫钙离子通道的结构和功能研究进展，以及钙离子通道在吡喹酮作用中的作用。
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