Xiao Shu-Hua
National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO collaborating Centre for Malaria, Schistosomiasis and Filariasis, Shanghai 200025, China.
Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2007 Dec;25(6):492-502.
Praziquantel is the only effective drug of choice against five human species of schistosomes. Main advantages of praziquantel include convenient oral administration, high safety and efficacy as well as short treatment course. To better understand the mode of action of praziquantel against schistosomes would be helpful for further development of new broad-spectrum anthelminthics. This paper summarizes the 30 years' research progress on the mode of action of the drug against schistosomes proceeded by domestic and abroad laboratories.
吡喹酮是治疗人体五种血吸虫病的唯一有效首选药物。吡喹酮的主要优点包括口服方便、安全性高、疗效好以及疗程短。深入了解吡喹酮抗血吸虫的作用机制将有助于新型广谱驱虫药的进一步研发。本文综述了国内外实验室对该药抗血吸虫作用机制30年来的研究进展。
