Formal total synthesis of (+)-gephyrotoxin.
作者信息
Santarem Marco, Vanucci-Bacqué Corinne, Lhommet Gérard
机构信息
UPMC Univ Paris 06, CNRS, UMR 7611, Laboratoire de Chimie Organique, Equipe Chimie des Hétérocycles, 4 Place Jussieu, F-75005 Paris, France.
出版信息
J Org Chem. 2008 Aug 15;73(16):6466-9. doi: 10.1021/jo801150e. Epub 2008 Jul 19.
PMID:18637692
Abstract
An efficient formal total synthesis of (+)-gephyrotoxin is described. The key step of our strategy relies on the diastereoselective reduction of a chiral pyrrolidine beta-enamino ester obtained by condensation of ( S)-phenylglycinol on a protected 8-hydroxy-3,6-dioxooctanoate.
摘要
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