（-）-组胺毒素285A和（-）-全氢组胺毒素的全合成。

Total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin.

作者信息

Macdonald James M, Horsley Helen T, Ryan John H, Saubern Simon, Holmes Andrew B

机构信息

CSIRO, Division of Molecular and Health Technologies, Bag 10, Clayton South, Victoria 3169, Australia.

出版信息

Org Lett. 2008 Oct 2;10(19):4227-9. doi: 10.1021/ol801604z. Epub 2008 Sep 3.

DOI:10.1021/ol801604z

PMID:18763799

Abstract

Starting from commercially available ( S)-glycidol, and via a common intermediate, the total synthesis of (-)-histrionicotoxin 285A and (-)-perhydrohistrionicotoxin has been achieved. Key to this synthesis was the efficient construction of a six-membered, chiral, cyclic nitrone.

摘要

从市售的（S）-缩水甘油出发，并通过一个共同的中间体，实现了（-）-组胺毒素285A和（-）-全氢组胺毒素的全合成。该合成的关键在于高效构建一个六元手性环状硝酮。