结肠和结直肠癌干细胞：寻找潜在生物标志物的进展
Colonic and colorectal cancer stem cells: progress in the search for putative biomarkers.
作者信息
Willis Naomi D, Przyborski Stefan A, Hutchison Christopher J, Wilson Robert G
机构信息
School of Biological and Biomedical Sciences, Durham University, Durham, UK.
出版信息
J Anat. 2008 Jul;213(1):59-65. doi: 10.1111/j.1469-7580.2008.00917.x.
Abstract
The maintenance of healthy colonic crypts is dependent on the integrity of the adult epithelial stem cells located within them. Perturbations in stem cell dynamics are generally believed to represent the first step towards colorectal tumorigenesis. Experimental manipulation of intestinal stem cells has greatly increased our understanding of them, but further progress has been slowed due to the absence of a reliable stem cell biomarker. In this review we discuss the candidate colonic stem cell biomarkers which have been proposed. Furthermore, we investigate the putative biomarkers for so-called colorectal cancer stem cells, a highly aggressive subpopulation of cells considered to drive tumour development.
摘要
健康结肠隐窝的维持依赖于位于其中的成体上皮干细胞的完整性。干细胞动力学的紊乱通常被认为是结直肠癌发生的第一步。对肠道干细胞的实验操作极大地增进了我们对它们的了解，但由于缺乏可靠的干细胞生物标志物，进一步的进展有所放缓。在这篇综述中，我们讨论了已被提出的候选结肠干细胞生物标志物。此外，我们还研究了所谓的结直肠癌干细胞的假定生物标志物，这是一类被认为驱动肿瘤发展的极具侵袭性的细胞亚群。
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