Dallon John C, Ehrlich H Paul
Department of Surgery, Division of Plastic Surgery, Milton S. Hershey Medical Center, Hershey, Pennsylvania, USA.
Wound Repair Regen. 2008 Jul-Aug;16(4):472-9. doi: 10.1111/j.1524-475X.2008.00392.x.
Bell's introduction of the fibroblast-populated collagen lattice (FPCL) has facilitated the study of collagen-cell interactions. As a result of the numerous modifications of the casting of FPCLs, the in vivo applications of these in vitro findings have been confusing. Here experimental FPCL contraction findings are viewed in regard to three proposed mechanisms responsible for lattice contraction. The cellular mechanisms responsible for generating FPCL contraction are cell contraction, cell tractional forces related to cell locomotion, and initial cell elongation and spreading.
贝尔引入的成纤维细胞填充胶原晶格（FPCL）推动了对胶原-细胞相互作用的研究。由于对FPCL铸造进行了大量改进，这些体外研究结果在体内的应用一直令人困惑。在这里，从三种推测的导致晶格收缩的机制角度来看待实验性FPCL收缩的研究结果。导致FPCL收缩的细胞机制包括细胞收缩、与细胞移动相关的细胞牵引力，以及细胞最初的伸长和铺展。
