Graf Jürgen, Mühlhoff Cecile, Doig Gordon S, Reinartz Sebastian, Bode Kirsten, Dujardin Robert, Koch Karl-Christian, Roeb Elke, Janssens Uwe
Department of Anaesthesia and Intensive Care Medicine, Philipps-University Marburg, Baldingerstrasse, 35043 Marburg, Germany.
Crit Care. 2008;12(4):R92. doi: 10.1186/cc6963. Epub 2008 Jul 18.
The purpose of this study was to investigate the costs and health status outcomes of intensive care unit (ICU) admission in patients who present after sudden cardiac arrest with in-hospital or out-of-hospital cardiopulmonary resuscitation.
Five-year survival, health-related quality of life (Medical Outcome Survey Short Form-36 questionnaire, SF-36), ICU costs, hospital costs and post-hospital health care costs per survivor, costs per life year gained, and costs per quality-adjusted life year gained of patients admitted to a single ICU were assessed.
One hundred ten of 354 patients (31%) were alive 5 years after hospital discharge. The mean health status index of 5-year survivors was 0.77 (95% confidence interval 0.70 to 0.85). Women rated their health-related quality of life significantly better than men did (0.87 versus 0.74; P < 0.05). Costs per hospital discharge survivor were 49,952 euro. Including the costs of post-hospital discharge health care incurred during their remaining life span, the total costs per life year gained were 10,107 euro. Considering 5-year survivors only, the costs per life year gained were calculated as 9,816 euro or 14,487 euro per quality-adjusted life year gained. Including seven patients with severe neurological sequelae, costs per life year gained in 5-year survivors increased by 18% to 11,566 euro.
Patients who leave the hospital following cardiac arrest without severe neurological disabilities may expect a reasonable quality of life compared with age- and gender-matched controls. Quality-adjusted costs for this patient group appear to be within ranges considered reasonable for other groups of patients.
本研究旨在调查在院内心脏骤停或院外心脏骤停后接受心肺复苏的患者入住重症监护病房(ICU)的费用及健康状况结局。
评估了入住单一ICU的患者的5年生存率、健康相关生活质量(医学结局研究简表36问卷,SF - 36)、每位幸存者的ICU费用、住院费用及出院后医疗保健费用、每获得一个生命年的费用以及每获得一个质量调整生命年的费用。
354例患者中有110例(31%)在出院后5年存活。5年幸存者的平均健康状况指数为0.77(95%置信区间0.70至0.85)。女性对其健康相关生活质量的评分显著高于男性(0.87对0.74;P < 0.05)。每位出院幸存者的费用为49,952欧元。包括其剩余寿命期间产生的出院后医疗保健费用,每获得一个生命年的总费用为10,107欧元。仅考虑5年幸存者,每获得一个生命年的费用计算为9,816欧元,或每获得一个质量调整生命年的费用为14,487欧元。纳入7例有严重神经后遗症的患者后,5年幸存者每获得一个生命年的费用增加18%,至11,566欧元。
与年龄和性别匹配的对照组相比,心脏骤停后出院且无严重神经功能障碍的患者可能预期有合理的生活质量。该患者群体的质量调整费用似乎在其他患者群体认为合理的范围内。