Department of Paediatric Neurology, Prince of Wales Children's Hospital, Sydney, Australia.
J Clin Neurosci. 1997 Apr;4(2):173-5. doi: 10.1016/s0967-5868(97)90069-2.
We investigated the effect of morphine, midazolam and their active metabolites on background electroencephalogram (EEG) in 6 neonates undergoing extracorporeal membrane oxygenation (ECMO) by conducting simultaneous EEGs and serum drug levels. Despite serum levels that were sufficient to produce adequate sedation, no patients had burstsuppressed or flat EEG backgrounds. We did, however, note that scalp oedema caused by prolonged immobility led to artefactual attenuation of EEG background. We conclude that an EEG prior to sedation will provide important baseline information that allows subsequent comparison and an awareness that scalp oedema after prolonged sedation and immobility will reduce misinterpretation of artefactual EEG attenuation.
我们通过同时进行脑电图和血清药物水平检测，研究了吗啡、咪达唑仑及其活性代谢物对 6 例接受体外膜肺氧合（ECMO）的新生儿背景脑电图（EEG）的影响。尽管血清水平足以产生足够的镇静效果，但没有患者的 EEG 背景出现爆发抑制或平坦。然而，我们注意到，由于长时间不动引起的头皮水肿导致 EEG 背景的人为衰减。我们得出结论，镇静前的 EEG 将提供重要的基线信息，允许随后进行比较，并意识到长时间镇静和不动后头皮水肿会降低对人为 EEG 衰减的错误解释。
