人类重复刺激斑贴试验实施与解读中的关键因素综述
A review of critical factors in the conduct and interpretation of the human repeat insult patch test.
作者信息
McNamee Pauline M, Api Anne Marie, Basketter David A, Frank Gerberick G, Gilpin Deborah A, Hall Barbara M, Jowsey Ian, Robinson Michael K
机构信息
The Procter & Gamble Company, Whitehall Lane, Egham, Surrey TW209NW, UK.
出版信息
Regul Toxicol Pharmacol. 2008 Oct;52(1):24-34. doi: 10.1016/j.yrtph.2007.10.019. Epub 2007 Dec 4.
This paper reviews key factors that are critical to the conduct and interpretation of Human Repeat Insult Patch Tests (HRIPTs). A methodology for HRIP testing is described and general guidelines for evaluation of responses indicative of induction and elicitation of skin sensitization and skin irritation are detailed. Understanding and applying these key factors is crucial to the design of such studies and reliability of the resulting data when used in the overall risk assessment process.
本文回顾了对人体重复刺激斑贴试验（HRIPTs）的实施和解读至关重要的关键因素。描述了HRIP测试的一种方法，并详细阐述了评估表明皮肤致敏和皮肤刺激的诱导和激发反应的一般指南。理解和应用这些关键因素对于此类研究的设计以及在整体风险评估过程中使用所得数据的可靠性至关重要。
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