Ding Wei-Qun, Yu Hai-Jun, Lind Stuart E
Department of Pathology, University of Oklahoma Health Sciences Center, 975 NE 10th Street, BRC 411A, Oklahoma City, OK 73104, USA.
Cancer Lett. 2008 Nov 28;271(2):251-9. doi: 10.1016/j.canlet.2008.06.011. Epub 2008 Jul 18.
Metal-binding compounds have been shown to have anticancer activity and are being evaluated clinically as anticancer agents. We have recently found that a zinc-binding compound, 5-chloro-7-iodo-8-hydroxyquinoline (clioquinol), kills cancer cells by transporting zinc into the cells. We therefore compared the action of clioquinol with two other cytotoxic zinc-binding compounds, N,N,N',N'-tetrakis(2-pyridylmethyl)ethylenediamine (TPEN) and pyrrolidine dithiocarbamate (PDTC). We demonstrate that metal-binding compounds can be subclassified based upon the reversibility of their cytotoxicity by metal supplementation and their modes of action. Understanding the mechanisms whereby metal-binding compounds affect cell behavior may aid in their optimization for clinical use.
金属结合化合物已显示出具有抗癌活性，并且正在作为抗癌剂进行临床评估。我们最近发现一种锌结合化合物，5-氯-7-碘-8-羟基喹啉（氯碘羟喹），通过将锌转运到细胞中来杀死癌细胞。因此，我们将氯碘羟喹的作用与另外两种细胞毒性锌结合化合物，N,N,N',N'-四（2-吡啶甲基）乙二胺（TPEN）和吡咯烷二硫代氨基甲酸盐（PDTC）进行了比较。我们证明，金属结合化合物可以根据其细胞毒性通过金属补充的可逆性及其作用方式进行亚分类。了解金属结合化合物影响细胞行为的机制可能有助于其临床应用的优化。
