Heberlein Annemarie, Bleich Stefan, Bayerlein Kristina, Frieling Helge, Gröschl Michael, Kornhuber Johannes, Hillemacher Thomas
Department of Psychiatry and Psychotherapy, University Hospital Erlangen-Nuremberg, Schwabachanlage 6, D-91054 Erlangen, Germany.
Psychoneuroendocrinology. 2008 Aug;33(7):999-1003. doi: 10.1016/j.psyneuen.2008.05.011. Epub 2008 Jul 21.
Recent studies show that alcohol dependence is associated with alterations in plasma levels of nerve growth factor (NGF). The aim of this study was to further elucidate reported alterations in NGF plasma levels during alcohol intoxication and withdrawal. Therefore, we assessed NGF plasma levels by enzyme-linked immunosorbent assay (ELISA) on admission (day 0) and day 7 of alcohol withdrawal in male alcohol dependent patients (n=75) in comparison to healthy controls (n=44). We found significant higher (U=1005.0, p<0.001) NGF plasma levels in the alcohol-dependent patients. Subgroup analysis showed significant higher (U=-2.934, p=0.003) NGF plasma levels in patients suffering from acute alcohol intoxication (group A) than in early abstinent patients (group B). From day 0 to day 7 of alcohol withdrawal NGF plasma levels decreased significantly in both groups (group A: Z=-3.118, p=0.002, group B: Z=-2.103, p=0.035). Our results suggest that acute alcohol intoxication is associated with an increase in NGF plasma levels, which decrease during alcohol withdrawal. These results suggest that NGF plasma levels increase as part of a regulation mechanism that counteracts alcohol intoxication.
近期研究表明，酒精依赖与血浆神经生长因子（NGF）水平的改变有关。本研究的目的是进一步阐明酒精中毒和戒断期间NGF血浆水平的变化。因此，我们采用酶联免疫吸附测定（ELISA）法，对75例男性酒精依赖患者（研究对象）和44例健康对照者在入院时（第0天）及酒精戒断第7天的NGF血浆水平进行了评估。我们发现，酒精依赖患者的NGF血浆水平显著更高（U = 1005.0，p < 0.001）。亚组分析显示，急性酒精中毒患者（A组）的NGF血浆水平显著高于早期戒酒患者（B组）（U = -2.934，p = 0.003）。从酒精戒断第0天到第7天，两组患者的NGF血浆水平均显著下降（A组：Z = -3.118，p = 0.002；B组：Z = -2.103，p = 0.035）。我们的研究结果表明，急性酒精中毒与NGF血浆水平升高有关，而在酒精戒断期间该水平会下降。这些结果表明，NGF血浆水平升高是对抗酒精中毒调节机制的一部分。
