Blommaert F, Cassano W F, Croker B P
Department of Pathology, University of Florida College of Medicine, Gainesville 32610.
Clin Immunol Immunopathol. 1991 Sep;60(3):430-42. doi: 10.1016/0090-1229(91)90099-v.
We have generated three murine monoclonal antibodies to the new human osteosarcoma cell line 4444T. Analysis of their binding patterns to tumor cell lines, normal human tissues, and surgical tumor specimens indicates that the antibodies recognize a subset of human sarcomas and stromal tissues but fail to react with carcinomas or normal human epithelial tissue. These mesenchyme-specific monoclonal antibodies bind to antigens in the extracellular matrix. One antibody is specific in its binding to the muscularis arteriosus. We expect these antibodies to aid in the identification of sarcomas and to extend our knowledge of the components of the extracellular matrix and its interaction with tumors.
我们已经针对新的人骨肉瘤细胞系4444T产生了三种鼠单克隆抗体。对它们与肿瘤细胞系、正常人组织及手术肿瘤标本的结合模式分析表明，这些抗体识别一部分人肉瘤和间质组织，但不与癌或正常人上皮组织发生反应。这些间充质特异性单克隆抗体与细胞外基质中的抗原结合。一种抗体在与动脉肌层的结合上具有特异性。我们期望这些抗体有助于肉瘤的识别，并扩展我们对细胞外基质成分及其与肿瘤相互作用的认识。
