Chaiban Joumana T, Bitar Fadi F, Azar Sami T
Department of Internal Medicine, American University of Beirut-Medical Center, Beirut 11072020, Lebanon.
Metabolism. 2008 Aug;57(8):1019-22. doi: 10.1016/j.metabol.2007.02.011.
The endocrine system plays an important role in the adaptation to hypoxia. The aim of this study was to assess the effect of chronic hypoxia on insulin, adiponectin, leptin, and ghrelin levels in a neonatal animal model. Sprague-Dawley rats were placed in a normobaric hypoxic environment at birth. Controls remained in room air. Rats were killed at 2 and 8 weeks of life. Insulin, adiponectin, leptin, and ghrelin were measured. At 2 weeks of life, there was no significant difference in insulin, adiponectin, and leptin levels between the hypoxic and control rats. The only statistically significant difference was found in ghrelin levels, which were lower in the hypoxic group (3.19 +/- 3.35 vs 24.52 +/- 5.09 pg/mL; P < .05). At 8 weeks of life, insulin was significantly higher in the hypoxic group (0.72 +/- 0.14 vs 0.44 +/- 0.26 ng/mL; P < .05) and adiponectin was significantly lower (1257.5 +/- 789.5 vs 7817.3 +/- 8453.7 ng/mL; P < .05). Leptin and ghrelin did not show significant difference in this age group, but leptin level per body weight was higher in the hypoxic group. Finally, we conclude that 2 weeks of continuous neonatal hypoxic exposure leads to a decrease in plasma ghrelin only with no significant change in insulin, adiponectin, and leptin and that 8 weeks of hypoxia leads to a decrease in adiponectin with an increase in insulin despite a significant decrease in weight.
内分泌系统在对缺氧的适应过程中发挥着重要作用。本研究的目的是评估慢性缺氧对新生动物模型中胰岛素、脂联素、瘦素和胃饥饿素水平的影响。出生时将斯普拉格-道利大鼠置于常压缺氧环境中。对照组置于正常空气中。在大鼠2周和8周龄时将其处死。测量胰岛素、脂联素、瘦素和胃饥饿素水平。在2周龄时，缺氧组和对照组大鼠的胰岛素、脂联素和瘦素水平无显著差异。仅在胃饥饿素水平上发现了统计学上的显著差异，缺氧组的胃饥饿素水平较低（3.19±3.35 vs 24.52±5.09 pg/mL；P<.05）。在8周龄时，缺氧组的胰岛素水平显著升高（0.72±0.14 vs 0.44±0.26 ng/mL；P<.05），而脂联素水平显著降低（1257.5±789.5 vs 7817.3±8453.7 ng/mL；P<.05）。在这个年龄组中，瘦素和胃饥饿素没有显示出显著差异，但缺氧组每体重的瘦素水平较高。最后，我们得出结论，新生儿连续2周缺氧暴露仅导致血浆胃饥饿素降低，胰岛素、脂联素和瘦素无显著变化；而8周缺氧导致脂联素降低，胰岛素升高，尽管体重显著下降。
