Zaal M J, Maudgal P C, Rietveld E, Suir E P
Department of Ophthalmology, Academisch Ziekenhuis Vrije Universiteit, Amsterdam, The Netherlands.
Curr Eye Res. 1991;10 Suppl:125-30. doi: 10.3109/02713689109020368.
In a prospective open trial 40 patients suffering from acute herpes zoster ophthalmicus were treated with systemic acyclovir. An additional 10 patients were treated by topical acyclovir alone and dexamethasone eye-drops were administered to 5 of them to suppress ocular inflammation. In the topical treatment group the period of new skin lesion formation and progression of ocular inflammatory signs were significantly prolonged. Therapy with systemic acyclovir however resulted in a quick and complete resolution of ocular inflammation in all patients. Chronic ocular inflammation developed in 4 out of 10 patients treated with topical acyclovir. We consider chronic ocular zoster as a distinct clinical entity, possibly expressing a failing local immune response against VZV.
在一项前瞻性开放试验中，40例急性眼带状疱疹患者接受了全身性阿昔洛韦治疗。另外10例患者仅接受局部阿昔洛韦治疗，其中5例给予地塞米松滴眼液以抑制眼部炎症。在局部治疗组中，新皮肤病变形成期和眼部炎症体征进展期显著延长。然而，全身性阿昔洛韦治疗使所有患者的眼部炎症迅速完全消退。10例接受局部阿昔洛韦治疗的患者中有4例发生了慢性眼部炎症。我们认为慢性眼部带状疱疹是一种独特的临床实体，可能表明针对水痘-带状疱疹病毒的局部免疫反应失败。
