Marsh R J, Cooper M
Department of Clinical Ophthalmology, Moorfields Eye Hospital, London.
Br J Ophthalmol. 1991 Sep;75(9):542-6. doi: 10.1136/bjo.75.9.542.
Ninety seven new patients with ophthalmic zoster were randomly allocated to three topical treatment groups: acyclovir (ACV) ointment and placebo drops (AP), placebo ointment with steroid drops (PS), and acyclovir ointment with steroid drops (AS). The dosage administered was determined by the score of the ocular inflammation. Follow-up was for at least one year. The results showed that topical ACV alone is insufficient for severe ocular inflammation but is not inclined to lead to recurrences in milder cases. Topical steroid alone is effective but tends to necessitate prolonged treatment. Combined steroid and ACV is questionably better than steroid alone and causes marginally fewer rebound inflammations.
97名新诊断为眼部带状疱疹的患者被随机分配到三个局部治疗组：阿昔洛韦（ACV）软膏和安慰剂滴眼液（AP）组、安慰剂软膏和类固醇滴眼液（PS）组、阿昔洛韦软膏和类固醇滴眼液（AS）组。给药剂量根据眼部炎症评分确定。随访至少一年。结果表明，单独使用局部ACV对严重眼部炎症是不够的，但在较轻病例中不易导致复发。单独使用局部类固醇是有效的，但往往需要长期治疗。类固醇和ACV联合使用是否比单独使用类固醇更好存在疑问，且引起的反弹性炎症略少。
