Paige Carleitta, Reid Sean D, Hanna Philip C, Claiborne Al
Center for Structural Biology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston-Salem, NC 27157, USA.
J Bacteriol. 2008 Sep;190(18):6271-5. doi: 10.1128/JB.00860-08. Epub 2008 Jul 18.
In Bacillus anthracis, the novel type III pantothenate kinase (PanK(Ba); encoded by coaX) catalyzes the first committed step in coenzyme A biosynthesis. We have demonstrated by analyzing the growth characteristics of a conditional coaX mutant that PanK(Ba) is an essential enzyme, thus contributing to its validation as a new antimicrobial target.
在炭疽芽孢杆菌中,新型III型泛酸激酶(PanK(Ba);由coaX编码)催化辅酶A生物合成中的首个关键步骤。通过分析条件性coaX突变体的生长特性,我们已证明PanK(Ba)是一种必需酶,从而有助于将其确认为一个新的抗菌靶点。