Teixeira Antonio Roberto Franchi, Molan Nilza Trindade, Bellodi-Privato Marta, Coelho Ana Maria, Leite Kátia Ramos, Seguro Antônio Carlos, Bacchella Telésforo, Machado Marcel Cerqueira César
Transplantation Division, Department of Gastroenterology, School of Medicine, USP, São Paulo, Brazil.
Acta Cir Bras. 2008 Jul-Aug;23(4):378-83. doi: 10.1590/s0102-86502008000400013.
To determine whether rosiglitazone-enriched diet offer protection in a classical model of liver ischemia-reperfusion injury in rats.
Two days before the experiment, rats were divided into 2 groups: Control Group (n=13) rats fed with standard diet; Rosi Group (n=13): rats fed with a powdered standard diet supplemented with rosiglitazone. The animals were submitted to liver ischemia-reperfusion by clamping the pedicle of median and left anterolateral lobes. After 1 hour of partial hepatic ischemia, the clamp was removed for reperfusion. After 2 or 24 hours (Control and Rosi Groups), blood was collected for enzymes and cytokines analysis. Ischemic and non-ischemic liver were collected for malondialdehyde analysis and histological assessment. Lungs were removed for tissue myeloperoxidase quantification.
There were no statistical differences between groups for all analysed parameters.
In this model, rosiglitazone-enriched diet did not protect liver against ischemia-reperfusion injury.
