Mizushima Y, Hoshi K, Yanagawa A, Takano K
Institute of Medical Science, St. Marianna University School of Medicine, Kawasaki, Japan.
Drugs Exp Clin Res. 1991;17(2):127-31.
A superoxide dismutase (SOD) cream containing 0.6 mg/ml of bovine SOD was prepared. It was applied locally onto the skin and mucosal lesions caused by progressive systemic sclerosis (PSS), systemic lupus erythematosus (SLE), Behçet's disease, herpes simplex and burns. The lesions and symptoms were rapidly improved in many cases after its administration, even when the symptoms were stabilized for several weeks before the treatment. Although the trial was open-labelled, the topical application of SOD was concluded to be effective for these conditions.
制备了一种含有0.6毫克/毫升牛超氧化物歧化酶（SOD）的乳膏。将其局部应用于由进行性系统性硬化症（PSS）、系统性红斑狼疮（SLE）、白塞病、单纯疱疹和烧伤引起的皮肤及黏膜损伤处。在给药后，许多病例中的损伤和症状迅速改善，即使在治疗前症状已稳定数周。尽管该试验为开放性标签试验，但得出结论认为SOD局部应用对这些病症有效。
