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Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909.

作者信息

Pögün S, Scheffel U, Kuhar M J

机构信息

Department of Radiology, Johns Hopkins Medical Institutions, Baltimore, MD 21205.

出版信息

Eur J Pharmacol. 1991 Jun 6;198(2-3):203-5. doi: 10.1016/0014-2999(91)90622-w.

DOI:10.1016/0014-2999(91)90622-w
PMID:1864307
Abstract

Previous studies have shown that [3H] WIN 35,428 binds preferentially to striatal cocaine receptors at the dopamine transporter after in vivo injection. In vivo binding competition studies were carried out to assess the relative rates of entry and occupancy of cocaine receptors by (-)-cocaine, mazindol and GBR 12909. After i.v. injection, (-)-cocaine occupied receptors relatively more rapidly than GBR 12,909 while mazindol was the slowest.

摘要

相似文献

1
Cocaine displaces [3H]WIN 35,428 binding to dopamine uptake sites in vivo more rapidly than mazindol or GBR 12909.
Eur J Pharmacol. 1991 Jun 6;198(2-3):203-5. doi: 10.1016/0014-2999(91)90622-w.
2
Halogenated mazindol analogs as potential inhibitors of the cocaine binding site at the dopamine transporter.卤代马吲哚类似物作为多巴胺转运体上可卡因结合位点的潜在抑制剂。
J Med Chem. 1996 Dec 6;39(25):4935-41. doi: 10.1021/jm960288w.
3
Differential sensitivity to NaCl for inhibitors and substrates that recognize mutually exclusive binding sites on the neuronal transporter of dopamine in rat striatal membranes.大鼠纹状体膜中多巴胺神经元转运体上识别相互排斥结合位点的抑制剂和底物对氯化钠的差异敏感性。
Neurosci Res. 2001 Mar;39(3):319-25. doi: 10.1016/s0168-0102(00)00230-3.
4
Radiolabeling of dopamine uptake sites in mouse striatum: comparison of binding sites for cocaine, mazindol, and GBR 12935.小鼠纹状体中多巴胺摄取位点的放射性标记：可卡因、马吲哚和GBR 12935结合位点的比较。
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5
Translocation of dopamine and binding of 2 beta-carbomethoxy-3 beta-(4-fluorophenyl) tropane (WIN 35,428) measured under identical conditions in rat striatal synaptosomal preparations. Inhibition by various blockers.在相同条件下，于大鼠纹状体突触体标本中测量多巴胺的转运以及2β-甲氧羰基-3β-(4-氟苯基)托烷（WIN 35,428）的结合情况。各种阻滞剂的抑制作用。
Biochem Pharmacol. 1995 Jan 31;49(3):339-50. doi: 10.1016/0006-2952(94)00485-5.
6
In vivo labeling of cocaine binding sites on dopamine transporters with [3H]WIN 35,428.用[3H]WIN 35,428对多巴胺转运体上的可卡因结合位点进行体内标记。
J Pharmacol Exp Ther. 1991 Jun;257(3):954-8.
7
Comparison of [3H]WIN 35,428 binding, a marker for dopamine transporter, in embryonic mesencephalic neuronal cultures with striatal membranes of adult rats.在胚胎中脑神经元培养物中，以成年大鼠纹状体膜为对照，对作为多巴胺转运体标志物的[3H]WIN 35,428结合进行比较。
J Neurochem. 1993 Feb;60(2):469-76. doi: 10.1111/j.1471-4159.1993.tb03174.x.
8
Evidence that pure uptake inhibitors including cocaine interact slowly with the dopamine neuronal carrier.包括可卡因在内的纯摄取抑制剂与多巴胺神经元载体相互作用缓慢的证据。
Eur J Pharmacol. 1994 Nov 3;264(3):391-8. doi: 10.1016/0014-2999(94)00502-8.
9
Cations affect [3H]mazindol and [3H]WIN 35,428 binding to the human dopamine transporter in a similar fashion.
J Neurochem. 1997 Sep;69(3):1106-18. doi: 10.1046/j.1471-4159.1997.69031106.x.
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WIN 35,428 and mazindol are mutually exclusive in binding to the cloned human dopamine transporter.WIN 35,428和马吲哚在与克隆的人类多巴胺转运体结合方面相互排斥。
J Pharmacol Exp Ther. 1997 Aug;282(2):920-7.

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