Zahm J M, King M, Duvivier C, Pierrot D, Girod S, Puchelle E
INSERM U.314, Université de Reims, France.
Eur Respir J. 1991 Mar;4(3):311-5.
The role of repetitive simulated coughing on the clearance of gel mucus simulant was investigated in vitro, by using a simulated cough machine. The repetition of cough induced a significant increase (p less than 0.01) in mucus simulant clearance (139.3 +/- 78.7 mm) in comparison to a single cough (24.9 +/- 27.5 mm). Moreover, the increase in frequency of the repetitive coughing induced a marked and significant increase in mucus simulant clearance (75.4 +/- 51.1 mm and 139.3 +/- 78.7 mm at 0.1 Hz and 1.6 Hz frequency, respectively). A significant (p less than 0.05) correlation was observed between the percentage increase of clearance and both shear-thinning index (r = 0.62) and the thixotropic index (r = 0.63). These results suggest that the shear-dependent properties of mucus, associated with a repetitive coughing, may increase the efficiency of mucus clearance by air flow mechanisms.
通过使用模拟咳嗽机，在体外研究了重复性模拟咳嗽对凝胶黏液模拟物清除的作用。与单次咳嗽（24.9±27.5毫米）相比，咳嗽的重复导致黏液模拟物清除率显著增加（p<0.01）（139.3±78.7毫米）。此外，重复性咳嗽频率的增加导致黏液模拟物清除率显著增加（在0.1赫兹和1.6赫兹频率下分别为75.4±51.1毫米和139.3±78.7毫米）。在清除率增加百分比与剪切变稀指数（r=0.62）和触变指数（r=0.63）之间观察到显著（p<0.05）相关性。这些结果表明，与重复性咳嗽相关的黏液剪切依赖性特性可能通过气流机制提高黏液清除效率。
