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用于细胞分选现象的自推进粒子模型。

Self-propelled particle model for cell-sorting phenomena.

作者信息

Belmonte Julio M, Thomas Gilberto L, Brunnet Leonardo G, de Almeida Rita M C, Chaté Hugues

机构信息

Instituto de Física, Universidade Federal do Rio Grande do Sul, Avenida Bento Gonçalves, 9500, P.B. 15051, 91501-970 Porto Alegre, Brazil.

出版信息

Phys Rev Lett. 2008 Jun 20;100(24):248702. doi: 10.1103/PhysRevLett.100.248702.

Abstract

A self-propelled particle model is introduced to study cell sorting occurring in some living organisms. This allows us to evaluate the influence of intrinsic cell motility separately from differential adhesion with fluctuations, a mechanism previously shown to be sufficient to explain a variety of cell rearrangement processes. We find that the tendency of cells to actively follow their neighbors greatly reduces segregation time scales. A finite-size analysis of the sorting process reveals clear algebraic growth laws as in physical phase-ordering processes, albeit with unusual scaling exponents.

摘要

引入了一个自驱动粒子模型来研究一些生物体中发生的细胞分选现象。这使我们能够分别评估内在细胞运动性的影响,而不受波动的差异黏附的影响,此前已证明这种机制足以解释各种细胞重排过程。我们发现细胞主动跟随其邻居的趋势大大缩短了分离时间尺度。对分选过程的有限尺寸分析揭示了与物理相序过程中类似的清晰代数增长规律,尽管具有不同寻常的标度指数。

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