早期蕈样肉芽肿的预后不受表型和T细胞克隆性的影响。

The prognosis of early mycosis fungoides is not influenced by phenotype and T-cell clonality.

作者信息

Massone C, Crisman G, Kerl H, Cerroni L

机构信息

Research Unit of Dermatopathology, Department of Dermatology, Medical University of Graz, Auenbruggerplatz 8, A-8036 Graz, Austria.

出版信息

Br J Dermatol. 2008 Sep;159(4):881-6. doi: 10.1111/j.1365-2133.2008.08761.x. Epub 2008 Jul 17.

DOI:10.1111/j.1365-2133.2008.08761.x

PMID:18644018

Abstract

BACKGROUND

The influence of phenotype and detection of clonality on prognosis in early mycosis fungoides has never been addressed in large studies.

OBJECTIVES

To correlate immunophenotype and detection of clonality with clinical outcome.

METHODS

We analysed 73 biopsy specimens from 68 patients with early mycosis fungoides (stage Ia or Ib) and at least 10 years of follow up (or dead of disease).

RESULTS

Four phenotypic groups could be identified: group A (alpha/beta+ CD4+ CD8- TIA1-), 51 patients; median survival time 160 months; group B (alpha/beta+ CD4- CD8+ TIA1+), 10 patients; median survival time 195 months; group C (alpha/beta- CD4- CD8+/- TIA1+), five patients; median survival time 165 months; and group D (alpha/beta+ CD4- CD8- TIA1-), two patients; median survival time 130 months. Survival curves did not show statistical differences among the groups. Monoclonality was detected in 36 of 67 tested biopsies (54%), and statistical analyses did not show prognostic differences between the clonal and nonclonal cases.

CONCLUSIONS

We conclude that cytotoxic phenotype and detection of monoclonal T-cell receptor-gamma gene rearrangement in early lesions of mycosis fungoides do not have any prognostic significance.

摘要

背景

在大型研究中，从未探讨过早期蕈样肉芽肿的表型和克隆性检测对预后的影响。

目的

将免疫表型和克隆性检测与临床结局相关联。

方法

我们分析了68例早期蕈样肉芽肿（Ia期或Ib期）患者的73份活检标本，这些患者至少随访了10年（或死于该疾病）。

结果

可识别出四个表型组：A组（α/β⁺ CD4⁺ CD8⁻ TIA1⁻），51例患者；中位生存时间160个月；B组（α/β⁺ CD4⁻ CD8⁺ TIA1⁺），10例患者；中位生存时间195个月；C组（α/β⁻ CD4⁻ CD8⁺/⁻ TIA1⁺），5例患者；中位生存时间165个月；D组（α/β⁺ CD4⁻ CD8⁻ TIA1⁻），2例患者；中位生存时间130个月。各生存曲线在组间未显示出统计学差异。在67份检测的活检标本中有36份（54%）检测到单克隆性，统计学分析未显示克隆性和非克隆性病例之间的预后差异。