Nagshabandi Khalid Nabil, Shadid Abdulrahman, Shadid Asem, Almuhanna Nouf K
Department of Dermatology, King Saud University and King Saud University Medical City, Riyadh.
College of Medicine, King Saud University, Riyadh.
Dermatol Reports. 2024 Apr 12;16(4):9908. doi: 10.4081/dr.2024.9908. eCollection 2024 Nov 21.
Mycosis fungoides (MF) stands as the predominant form of primary cutaneous T-cell lymphoma (CTCL). It manifests a diverse array of clinical, histological, and immunophenotypic variations, each bearing distinct prognostic implications. The typical immunophenotypic profile of mycosis fungoides involves CD3+/CD4+/CD45RO+ memory T cells. Notably, the CD4-/CD8- double-negative variant of MF is a rare occurrence, observed in approximately 12% of early-stage cases and more prevalent in tumor-stage instances, often correlated with atypical clinical presentations. Despite its rarity, scant information is available about double-negative mycosis fungoides, with only a limited number of cases documented in the existing literature. This review aims to provide enhanced clarity, comprehension, and a detailed exploration of the spectrum encompassing double-negative mycosis fungoides.
蕈样肉芽肿（MF）是原发性皮肤T细胞淋巴瘤（CTCL）的主要形式。它表现出各种各样的临床、组织学和免疫表型变异，每种变异都具有不同的预后意义。蕈样肉芽肿典型的免疫表型特征涉及CD3+/CD4+/CD45RO+记忆T细胞。值得注意的是，MF的CD4-/CD8-双阴性变异很少见，在约12%的早期病例中观察到，在肿瘤期病例中更常见，常与非典型临床表现相关。尽管罕见，但关于双阴性蕈样肉芽肿的信息很少，现有文献中记录的病例数量有限。本综述旨在更清晰、全面地详细探讨双阴性蕈样肉芽肿的相关情况。
