基因组稳定性：依赖FANCJ的G4 DNA修复
Genomic stability: FANCJ-dependent G4 DNA repair.
作者信息
Maizels Nancy
机构信息
Department of Immunology, University of Washington School of Medicine, 1959 NE Pacific St., Seattle, Washington 98195-7650, USA.
出版信息
Curr Biol. 2008 Jul 22;18(14):R613-4. doi: 10.1016/j.cub.2008.06.011.
Abstract
G-rich regions have the potential to form G4 DNA upon replication, which can lead to genomic instability. FANCJ, a G4 DNA helicase, has been shown to be critical for the stability of regions that match the G4 signature motif by experiments analyzing its nematode homolog.
摘要
富含鸟嘌呤（G）的区域在复制时有可能形成G4 DNA，这可能导致基因组不稳定。FANCJ是一种G4 DNA解旋酶，通过分析其线虫同源物的实验表明，它对于与G4特征基序匹配的区域的稳定性至关重要。
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