Mitchell I C, Turk J L
Royal College of Surgeons of England, London.
Gut. 1991 Feb;32(2):159-62. doi: 10.1136/gut.32.2.159.
Striking differences were observed between the visceral and cutaneous responses after tests with validated Kveim and normal spleen suspensions in a guinea pig model of granulomatous bowel disease. Five of six animals sensitised with BCG showed positive responses at the ileal Kveim test site whereas all six had negative cutaneous Kveim tests. Conversely, two of six animals sensitised with irradiated Mycobacterium leprae showed positive cutaneous Kveim tests and only one a positive response in the ascending colon. All six showed negative responses at the ileal Kveim test site. No positive visceral or cutaneous responses were observed in either group of animals after tests with normal spleen suspension. These findings are discussed in relation to the positive Kveim responses previously reported among patients with Crohn's disease, tuberculoid and lepromatous leprosy, and among seemingly healthy BCG vaccinated subjects. The findings provide further evidence in support of a possible mycobacterial aetiology for sarcoidosis and Crohn's disease.
在肉芽肿性肠病豚鼠模型中，用经过验证的克维姆（Kveim）试剂和正常脾脏悬液进行检测后，观察到内脏反应和皮肤反应之间存在显著差异。六只用卡介苗致敏的动物中，有五只在回肠克维姆试验部位呈阳性反应，而所有六只动物的皮肤克维姆试验均为阴性。相反，六只用经辐射的麻风分枝杆菌致敏的动物中，有两只皮肤克维姆试验呈阳性，只有一只在升结肠有阳性反应。所有六只在回肠克维姆试验部位均呈阴性反应。用正常脾脏悬液检测后，两组动物均未观察到阳性的内脏或皮肤反应。结合先前在克罗恩病、结核样型和瘤型麻风患者以及看似健康的卡介苗接种者中报道的克维姆阳性反应，对这些发现进行了讨论。这些发现为结节病和克罗恩病可能的分枝杆菌病因提供了进一步的证据。
