Babbs C, Warnes T W, Torrance H B, Ballardie F W
University Department of Gastroenterology Manchester Royal Infirmary.
Gut. 1991 Feb;32(2):225-6. doi: 10.1136/gut.32.2.225.
Renal glomerular changes are a well recognised complication of cirrhosis and are frequently characterised by mesangial IgA deposition. We report a patient with non-cirrhotic portal hypertension who developed IgA nephropathy and a nephrotic syndrome with renal histological changes classically associated with cirrhosis. Splenectomy with resection of a splenic artery aneurysm resulted in remission of the nephrotic syndrome. This case illustrates the factors which contribute to the pathogenesis of IgA nephropathy in liver disease.
肾小球改变是肝硬化一种公认的并发症，常表现为系膜IgA沉积。我们报告一例非肝硬化性门静脉高压患者，该患者发生了IgA肾病及肾病综合征，其肾脏组织学改变通常与肝硬化相关。脾切除并切除脾动脉动脉瘤后，肾病综合征缓解。该病例说明了肝病中导致IgA肾病发病机制的因素。
