Nakamura M, Ohishi A, Watanabe R, Kaneko K, Aosaki N, Iigaya T, Monma T, Sugiura H, Miyoshi Y, Hamaguchi K
Department of Internal Medicine, Kasumigaura National Hospital, Tsuchiura.
Intern Med. 1994 Aug;33(8):488-91. doi: 10.2169/internalmedicine.33.488.
A 69-year-old female was admitted to our hospital because of leg edema, proteinuria (2.1 g/day), and gross hematuria. She had non-alcoholic liver cirrhosis of unknown etiology. Esophageal varices also were found. Examination of the renal biopsy specimen revealed mesangial proliferative glomerulonephritis with IgA deposits. Propranolol was administered orally to reduce portal hypertension, resulting in a progressive decrease in urinary microalbumin excretion. This case suggests that portal hypertension is involved in the pathogenesis of IgA nephropathy in liver cirrhosis.
一名69岁女性因腿部水肿、蛋白尿（2.1克/天）和肉眼血尿入院。她患有病因不明的非酒精性肝硬化。还发现有食管静脉曲张。肾活检标本检查显示为伴有IgA沉积的系膜增生性肾小球肾炎。口服普萘洛尔以降低门静脉高压，结果尿微量白蛋白排泄逐渐减少。该病例提示门静脉高压参与了肝硬化患者IgA肾病的发病机制。
