Chandrasekar Pranatharthi, Ljungman Per T
Division of Infectious Diseases, Wayne State University School of Medicine, Karmanos Cancer Institute/Harper University Hospital, Detroit, MI 48201, USA.
Transplantation. 2008 Jul 27;86(2):183-91. doi: 10.1097/TP.0b013e318177de64.
Changes in clinical practice permit more patients to undergo hematopoietic stem-cell transplantation but also have increased the risk for invasive fungal infection (IFI) in this population. Given the difficulties in the diagnosis of fungal infection and the correlation between delays in therapy and poor outcome, earlier treatment, and prophylactic strategies are attractive options for the management of IFIs in high-risk patients. The selection of the most effective antifungal treatment strategy requires a thorough knowledge of IFI risk factors, potential causative organisms, and the safety and efficacy of appropriate antifungal agents.
临床实践的变化使更多患者能够接受造血干细胞移植，但也增加了该人群发生侵袭性真菌感染（IFI）的风险。鉴于真菌感染诊断存在困难，且治疗延迟与不良预后之间存在关联，早期治疗和预防策略是高危患者IFI管理的有吸引力的选择。选择最有效的抗真菌治疗策略需要全面了解IFI的危险因素、潜在致病微生物以及合适抗真菌药物的安全性和有效性。
