Yousem S A
Department of Pathology, Presbyterian-University Hospital University of Pittsburgh School of Medicine, PA 15213.
Hum Pathol. 1991 Jun;22(6):535-40. doi: 10.1016/0046-8177(91)90229-i.
While Wegener's granulomatosis is recognized primarily for its vascular destruction, the extravascular granuloma is an integral part of the inflammatory process. We report five illustrative cases of this phenomenon in which the necrotizing process appeared to be centered primarily on the airways. This was associated with multisystem disease and cavitary lung nodules, which probably resulted from extensive airway necrosis. Prognosis with conventional cytoxan and prednisone therapy was excellent. The differential diagnosis of bronchocentric Wegener's granulomatosis with bronchocentric granulomatosis, infection, and aspiration pneumonia is discussed.
虽然韦格纳肉芽肿主要因其血管破坏而被认识，但血管外肉芽肿是炎症过程的一个组成部分。我们报告了5例说明这种现象的病例，其中坏死过程似乎主要集中在气道。这与多系统疾病和肺空洞结节相关，后者可能是广泛气道坏死所致。采用传统的环磷酰胺和泼尼松治疗预后良好。文中还讨论了以支气管为中心的韦格纳肉芽肿与以支气管为中心的肉芽肿、感染及吸入性肺炎的鉴别诊断。
