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髋关节置换术中的非骨水泥型股骨柄——羟基磷灰石涂层型还是普通多孔型:有区别吗?基于一项对HA Omnifit股骨柄进行至少15年随访的前瞻性研究。

Uncemented stems in hip replacement--hydroxyapatite or plain porous: does it matter? Based on a prospective study of HA Omnifit stems at 15-years minimum follow-up.

作者信息

Epinette J-A, Manley M T

机构信息

Orthopaedic Research and Imaging Center in Arthroplasty, Bruay Labuissiere, France.

出版信息

Hip Int. 2008 Apr-Jun;18(2):69-74. doi: 10.1177/112070000801800201.

Abstract

For many years, acrylic cement has been regarded as the unique available means for a long term and secure fixation of components in hip arthroplasty. A new generation of uncemented implants coated in hydroxyapatite (HA) has arisen since the mid-1980s, aiming to provide a 'biological interface' between metal and surrounding bone, and thus the hydroxyapatite interface was defined some years ago as a distinct entity from both cemented and 'plain porous' fixation. Based upon our 20-year experience with the HA Omnifit stem, this paper aims to discuss the efficiency of hydroxyapatite as a means of fixation for femoral components in hip arthroplasty, then examine whether the addition of a calcium phosphate layer induces any adverse effects, and finally make comparisons between HA-coated versus porous hip stems reported in the literature. With respect to fixation of femoral components in hip arthroplasty we report excellent results from the partially coated HA Omnifit stem in our series, with 99.20% of survival rate at 17-year follow-up, these results being consistent and similar to other HA series in the literature. HA 'uncemented' fixation can therefore be considered reliable and efficient. Furthermore, two decades of hydroxyapatite coatings have resulted in the identification of no major adverse effects. In fact calcium phosphate ions participate in the physiological turn-over of bone remodelling, and the HA coating is replaced by new bone formation without any fibrous tissue layer. Since HA particles are biodegradable and do not produce any inflammatory reaction in the surrounding bone, fears of osteolysis or third body wear due to HA debris have not been confirmed. Finally, comparison between HA versus plain porous femoral components through the literature has demonstrated better results with HA than porous alone both in terms of the quantity and quality of bone remodelling, and the potential migration and subsidence of the stem.

摘要

多年来,骨水泥一直被视为髋关节置换术中实现假体长期牢固固定的唯一可用方法。自20世纪80年代中期以来,新一代涂有羟基磷灰石(HA)的非骨水泥型植入物应运而生,旨在在金属与周围骨骼之间提供一个“生物界面”,因此,羟基磷灰石界面在数年前就被定义为一种有别于骨水泥固定和“普通多孔”固定的独特形式。基于我们对HA Omnifit股骨柄长达20年的使用经验,本文旨在探讨羟基磷灰石作为髋关节置换术中股骨假体固定方式的有效性,接着研究磷酸钙涂层的添加是否会引发任何不良影响,最后对文献中报道的HA涂层股骨柄与多孔股骨柄进行比较。关于髋关节置换术中股骨假体的固定,我们报告了我们系列中部分涂层的HA Omnifit股骨柄取得的优异结果,在17年随访时生存率为99.20%,这些结果与文献中其他HA系列一致且相似。因此,HA“非骨水泥”固定可被认为是可靠且有效的。此外,二十年的羟基磷灰石涂层应用并未发现任何重大不良影响。事实上,磷酸钙离子参与了骨重塑的生理周转过程,HA涂层会被新骨形成所替代,且没有任何纤维组织层。由于HA颗粒具有生物可降解性,不会在周围骨骼中产生任何炎症反应,因此关于HA碎片导致骨溶解或第三体磨损的担忧并未得到证实。最后,通过文献对HA与普通多孔股骨假体进行比较表明,无论是在骨重塑的数量和质量方面,还是在假体的潜在移位和下沉方面,HA都比单纯多孔假体表现出更好的效果。

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