Yuwen Yanqing, Gao Yulong, Gao Honglei, Qi Xiaole, Li Tieqiang, Liu Wei, Wang Xiaomei
Division of Avian Infectious Diseases, National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China.
Avian Dis. 2008 Jun;52(2):284-90. doi: 10.1637/8175-111707-Reg.1.
Nucleotide sequences of the VP2 gene of eight infectious bursal disease viruses isolated from vaccinated chicken flocks in the northeast of China were determined. The sequence analysis showed that all of the isolates were also characterized by the vvIBDV conserved amino acid residues: 222A, 256I, 294I, and 299S. Four of them had one amino acid change (D-->N) at position 212 in VP2 major hydrophilic peak A, while two of the four isolates had another one (A-->V) at position 321 in major hydrophilic peak B. The other isolates were similar to the UK661 strain. Our findings demonstrated that the vvlBDV strains in the northeast of China could be diverse.
测定了从中国东北地区接种疫苗的鸡群中分离出的8株传染性法氏囊病病毒VP2基因的核苷酸序列。序列分析表明，所有分离株还具有vvIBDV保守氨基酸残基的特征：222A、256I、294I和299S。其中4株在VP2主要亲水区A的212位有一个氨基酸变化（D→N），而这4株分离株中的2株在主要亲水区B的321位有另一个氨基酸变化（A→V）。其他分离株与UK661株相似。我们的研究结果表明，中国东北地区的vvIBDV毒株可能具有多样性。
