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The Full Region of N-Terminal in Polymerase of IBDV Plays an Important Role in Viral Replication and Pathogenicity: Either Partial Region or Single Amino Acid V4I Substitution Does Not Completely Lead to the Virus Attenuation to Three-Yellow Chickens.IBDV 聚合酶 N 端全长在病毒复制和致病性中起重要作用：部分区域或单个氨基酸 V4I 取代都不会导致病毒对三黄鸡完全减毒。
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本文引用的文献

1
Infectious bursal disease virus in Algeria: Detection of highly pathogenic reassortant viruses.阿尔及利亚传染性法氏囊病病毒：高致病性重组病毒的检测。
Infect Genet Evol. 2018 Jun;60:48-57. doi: 10.1016/j.meegid.2018.01.029. Epub 2018 Feb 1.
2
Molecular characterization of field infectious bursal disease virus isolates from Nigeria.来自尼日利亚的传染性法氏囊病病毒分离株的分子特征
Vet World. 2016 Dec;9(12):1420-1428. doi: 10.14202/vetworld.2016.1420-1428. Epub 2016 Dec 15.
3
Molecular characterization of infectious bursal disease viruses from Pakistan.来自巴基斯坦的传染性法氏囊病病毒的分子特征
Arch Virol. 2016 Jul;161(7):2001-6. doi: 10.1007/s00705-016-2869-9. Epub 2016 Apr 23.
4
Naturally occurring reassortant infectious bursal disease virus in northern China.中国北方自然发生的传染性法氏囊病病毒重配株
Virus Res. 2015 May 4;203:92-5. doi: 10.1016/j.virusres.2015.04.003. Epub 2015 Apr 11.
5
Genetic characterization of South American infectious bursal disease virus reveals the existence of a distinct worldwide-spread genetic lineage.南美传染性法氏囊病病毒的基因特征揭示了一种独特的全球传播基因谱系的存在。
Avian Pathol. 2015;44(3):212-21. doi: 10.1080/03079457.2015.1025696. Epub 2015 Apr 2.
6
Molecular epidemiology studies on partial sequences of both genome segments reveal that reassortant infectious bursal disease viruses were dominantly prevalent in southern China during 2000-2012.对两个基因组片段的部分序列进行的分子流行病学研究表明，2000年至2012年期间，重组传染性法氏囊病病毒在中国南方占主导地位。
Arch Virol. 2014 Dec;159(12):3279-92. doi: 10.1007/s00705-014-2195-z. Epub 2014 Aug 31.
7
Triplet amino acids located at positions 145/146/147 of the RNA polymerase of very virulent infectious bursal disease virus contribute to viral virulence.位置 145/146/147 的 RNA 聚合酶上的三联氨基酸有助于非常强毒传染性法氏囊病病毒的病毒毒力。
J Gen Virol. 2014 Apr;95(Pt 4):888-897. doi: 10.1099/vir.0.060194-0. Epub 2014 Jan 15.
8
Identification and pathogenicity of a natural reassortant between a very virulent serotype 1 infectious bursal disease virus (IBDV) and a serotype 2 IBDV.鉴定和致病性的一种非常毒力血清型 1 传染性法氏囊病病毒（IBDV）和血清型 2 IBDV 之间的自然重组。
Virology. 2011 Nov 25;420(2):98-105. doi: 10.1016/j.virol.2011.08.023. Epub 2011 Sep 28.
9
Sequence analysis of the VP2 hypervariable region of eight very virulent infectious bursal disease virus isolates from the northeast of China.来自中国东北地区的八株超强毒传染性法氏囊病病毒分离株VP2高变区的序列分析
Avian Dis. 2008 Jun;52(2):284-90. doi: 10.1637/8175-111707-Reg.1.
10
Phylogenetic analysis reveals a correlation between the expansion of very virulent infectious bursal disease virus and reassortment of its genome segment B.系统发育分析揭示了超强毒传染性法氏囊病病毒的扩张与其基因组片段B的重配之间的相关性。
J Virol. 2006 Sep;80(17):8503-9. doi: 10.1128/JVI.00585-06.

Pathogenic Characterization and Full Length Genome Sequence of a Reassortant Infectious Bursal Disease Virus Newly Isolated in Pakistan.

作者信息

Hussain Altaf, Wu Tiantian, Li Hui, Fan Linjin, Li Kai, Gao Li, Wang Yongqiang, Gao Yulong, Liu Changjun, Cui Hongyu, Pan Qing, Zhang Yanping, Aslam Asim, Muti-Ur-Rehman Khan, Munir Muhammad, Butt Salman Latif, Wang Xiaomei, Qi Xiaole

机构信息

Division of Avian Infectious Diseases, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, The Chinese Academy of Agricultural Sciences, Harbin, 150069, China.

OIE Reference Laboratory for Infectious Bursal Disease, Harbin, 150069, China.

出版信息

Virol Sin. 2019 Feb;34(1):102-105. doi: 10.1007/s12250-019-00082-8. Epub 2019 Feb 6.

DOI:10.1007/s12250-019-00082-8
PMID:30725319
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6420534/
Abstract
摘要