[茶多酚和表没食子儿没食子酸酯对血管紧张素II诱导的培养肥大心肌细胞的抑制作用]
[Inhibitory effect of tea polyphenols and EGCG on cultured hypertrophic myocyte induced by Ang II].
作者信息
Cui Wenming, Mao Weifeng, Du Haifang, Li Ning
机构信息
Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention, Beijing 100050, China.
出版信息
Wei Sheng Yan Jiu. 2008 May;37(3):356-8.
OBJECTIVE
To observe the potential effect of tea polyphenols and EGCG on cultured hypertrophic myocyte induced by Ang II.
METHODS
The study used cultured neonatal rat myocytes as a model to observe the potential effects of 10 microg/ml, 50 microg/ml and 100 microg/ml tea polyphenols and EGCG on hypertrophic myocyte induced by Ang II. We will measure the protein contents, the volume of myocyte, the numbers of fibrocasts.
RESULT
When compared to control group (untreated), the protein contents, the volume of myocytes, the numbers of fibrocasts in Ang II group increased. But all those in tea polyphenols and EGCG group decreased in a dose-dependent manner, when compared to Ang II group. However, the number of the myocyte cells in all groups has no significantly changed.
CONCLUSIONS
Tea polyphenols and EGCG can effectively inhibit hypertrophy of cultured neonatal rat heart myocytes induced by Ang II.
目的
观察茶多酚和表没食子儿没食子酸酯（EGCG）对血管紧张素II（Ang II）诱导的培养肥大心肌细胞的潜在作用。
方法
本研究以培养的新生大鼠心肌细胞为模型，观察10微克/毫升、50微克/毫升和100微克/毫升的茶多酚和EGCG对Ang II诱导的肥大心肌细胞的潜在作用。我们将测量蛋白质含量、心肌细胞体积、成纤维细胞数量。
结果
与对照组（未处理）相比，Ang II组的蛋白质含量、心肌细胞体积、成纤维细胞数量增加。但与Ang II组相比，茶多酚和EGCG组的所有这些指标均呈剂量依赖性降低。然而，所有组的心肌细胞数量没有明显变化。
结论
茶多酚和EGCG可有效抑制Ang II诱导的培养新生大鼠心脏心肌细胞肥大。
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